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Merck

PZ0178

Sigma-Aldrich

PHA 767491 hydrochloride

≥98% (HPLC)

Sinónimos:

1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C12H11N3O · xHCl
Número de CAS:
Peso molecular:
213.24 (free base basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

off-white to yellow

solubility

H2O: >25 mg/mL

SMILES string

Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3

InChI

1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H

InChI key

IMVNFURYBZMFDZ-UHFFFAOYSA-N

Application

PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage. It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells.

Biochem/physiol Actions

PHA 767491 serves as a potential anticancer drug. It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
Hamper S, et al.
Cell, 170(4), 774-786 (2017)
Medicinal Chemistry: Fusion of Traditional and Western Medicine, 382-382 (2014)
The Initiation of DNA Replication in Eukaryotes, 289-289 (2016)
Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage
Stork CT, et al.
eLife, 5, e17548-e17548 (2016)
Yang Lim et al.
Science (New York, N.Y.), 381(6664), eadi3448-eadi3448 (2023-08-17)
CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic replication initiation. In yeast, a multi-subunit "pre-loading complex" (pre-LC) accompanies GINS to chromatin-bound MCM2-7, leading to CMG formation. Here, we report that DONSON, a metazoan protein mutated in microcephalic primordial

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