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PZ0177

Sigma-Aldrich

OSU6162 hydrochloride

≥98% (HPLC)

Sinónimos:

PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C15H23NO2S·HCl
Número de CAS:
156907-84-5
Peso molecular:
317.87
MDL number:
MFCD09753276
UNSPSC Code:
51111800
PubChem Substance ID:
329823751
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -5 to -7°, c = 1 in methanol

color

white to tan

solubility

H2O: ≥16 mg/mL

storage temp.

−20°C

SMILES string

Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O

InChI

1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1

Inchi Key

LEMGVHZVBREXAD-PFEQFJNWSA-N

Biochem/physiol Actions

OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Nelleke Tolboom et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(2), 472-479 (2014-09-25)
(-)-OSU6162 is a dopamine stabilizer that can counteract both hyperdopaminergic and hypodopaminergic states. In this study, D2/D3 receptor occupancy of (-)-OSU6162 in the human brain was investigated using positron emission tomography (PET). Twelve male healthy volunteers underwent [(11)C]raclopride PET scanning

Artículos

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

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