PRS2325

Anti-CASPASE-12 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-Casp-12
• Número MDL: MFCD03454856
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: predicted mol wt 46 kDa
• reactividad de especies: rat, mouse, human
• técnicas: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso UniProt: O08736
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: mouse ... Casp12(12364)

Descripción

Descripción general

Caspase 12 (CASP12), a member of the caspase family, is expressed in the Golgi complex.

Inmunógeno

a peptide corresponding to amino acids 2-17 of murine caspase-12.

Aplicación

Anti-CASPASE-12 (ab1) antibody produced in rabbit has been used in western blotting.

Acciones bioquímicas o fisiológicas

Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP2325.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable