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P7032
Pyruvate Dehydrogenase from porcine heart
buffered aqueous glycerol solution, 0.1-1.0 units/mg protein (Lowry)
Sinónimos:
PDH, Pig heart pyruvate dehydrogenase
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About This Item
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Formulario
buffered aqueous glycerol solution
Nivel de calidad
actividad específica
0.1-1.0 units/mg protein (Lowry)
concentración
≥5.0 mg/mL
impurezas
polyethylene glycol, trace
actividad extraña
α-ketoglutarate dehydrogenase ≤15%
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
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Aplicación
Pyruvate dehydrogenase contributes to linking the glycolysis metabolic pathway to the citric acid cycle and releases energy via NADH. It is used to study how aerobic training effects pyruvate dehydrogenase [1]. It is also used to study the interaction between pyruvate dehydrogenase kinase and the pyruvate dehydrogenase complex[2] as well as the function and regulation of the pyruvate dehydrogenase complex. Product P7032 is provided in a buffered aqueous glycerol solution and is from porcine heart.
The enzyme has been used in a primary enzyme assay to test the ability of certain compounds to reduce PDK- (pyruvate dehydrogenase kinase) catalyzed PDC (pyruvate dehydrogenase complex) inactivation.[3]
Acciones bioquímicas o fisiológicas
Pyruvate dehydrogenase is involved in the decarboxylation of pyruvate and reductive acetylation of lipoic acid within the pyruvate dehydrogenase complex (PDC). Pyruvate dehydrogenase kinase (PDK) inactivates pyruvate dehydrogenase while pyruvate dehydrogenase phosphatase activates pyruvate dehydrogenase[4].
Definición de unidad
One unit will convert 1.0 μmole of β-NAD to β-NADH per min at pH 7.4 at 30 °C in the presence of saturating levels of Coenzyme A.
Forma física
Supplied as a 50% glycerol solution containing ~9 mg/mL bovine serum albumin, 30% sucrose, 1.5 mM EDTA, 1.5 mM EGTA, 1.5 mM 2-mercaptoethanol, 0.3 TRITON® X-100, 0.003% sodium azide, and 15 mM potassium phosphate, pH 6.8
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Aquatic Chronic 3
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Function and regulation of mammalian pyruvate dehydrogenase complex. Acetylation, interlipoyl acetyl transfer, and migration of the pyruvate dehydrogenase component.
R L Cate et al.
The Journal of biological chemistry, 254(5), 1659-1665 (1979-03-10)
Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.
D A Popp et al.
The Journal of biological chemistry, 255(16), 7540-7543 (1980-08-25)
Naoyuki Makita et al.
The Journal of pharmacy and pharmacology, 69(1), 43-51 (2016-10-21)
Recently, there has been a growing interest in the mechanism of action of dichloroacetate (DCA) for T-cell differentiation; however, this mechanism has not been elucidated in detail. Therefore, this study aimed to investigate the mechanism of action of DCA for
T D Aicher et al.
Bioorganic & medicinal chemistry letters, 9(15), 2223-2228 (1999-08-28)
Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single
Suzanne D DeBrosse et al.
Molecular genetics and metabolism, 107(3), 394-402 (2012-10-02)
Pyruvate dehydrogenase complex (PDC) deficiency is a relatively common mitochondrial disorder that primarily presents with neurological manifestations and lactic acidemia. We analyzed the clinical outcomes and neurological features of 59 consented symptomatic subjects (27 M, 32 F), who were confirmed
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Hi I want to know what is the expiration for this product? e.g. 1 year, 2 years,3 years. Thanks, Aviv.
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