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Merck

P1319

Sigma-Aldrich

Thyrotropin releasing hormone

≥98% (HPLC), powder

Sinónimos:

pGlu-His-Pro amide

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About This Item

Fórmula empírica (notación de Hill):
C16H22N6O4
Número de CAS:
Peso molecular:
362.38
Beilstein/REAXYS Number:
770238
EC Number:
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.32

biological source

human

assay

≥98% (HPLC)

form

powder

mol wt

362.38

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

impurities

22.6-23.8% Nitrogen
51.9-54.1% carbon

solubility

water: 25 mg/mL, cloudy, colorless to faintly yellow

UniProt accession no.

storage temp.

−20°C

SMILES string

NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3

InChI

1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1

InChI key

XNSAINXGIQZQOO-SRVKXCTJSA-N

Gene Information

human ... TRH(7200) , TRHR(7201)
mouse ... Trhr(22045)

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Amino Acid Sequence

Glp-His-Pro-NH2

General description

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.

Application

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.

Biochem/physiol Actions

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Visite la Librería de documentos

Erzsébet Gáspár et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 393-403 (2009-10-15)
Thyrotropin-releasing hormone (TRH) is the most proximal component of the hypothalamic-pituitary-thyroid axis that regulates thyroid hormone synthesis. Since transcripts for members of this axis were detected in cultured normal human skin cells and since human hair follicles (HFs) respond to
Laura Domínguez et al.
Brain, behavior and evolution, 71(3), 231-246 (2008-04-03)
To improve knowledge of the peptidergic systems in the brain of amphibians we have conducted a comparative analysis of the distribution of TRH immunoreactive cell bodies and fibers in three species of urodeles. Fiber labeling was observed in all main
Thyrotropin-Releasing Hormone
Jackson I M D
The New England Journal of Medicine, 306, 145-155 (1982)
Advantage of double labeled in situ hybridization for detecting the effects of glucocorticoids on the mRNAs of protooncogenes and neural peptides (TRH) in cultured hypothalamic neurons.
Luo LG and Jackson IM
Brain Research. Brain Research Protocols, 4(2), 201-208 (1999)
Vladimír Štrbák
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(1), 378-384 (2018-10-05)
Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin. High perinatal changes of the TRH gene expression and TRH concentrations in rat pancreatic islets coincide with the perinatal

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