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N4396

Sigma-Aldrich

Nalbuphine hydrochloride hydrate

≥98% (HPLC), powder, μ and κ opioid receptors agonist

Sinónimos:

17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride hydrate

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About This Item

Fórmula empírica (notación de Hill):
C21H27NO4 · HCl · xH2O
Número de CAS:
23277-43-2
Peso molecular:
393.90 (anhydrous basis)
EC Number:
245-549-9
UNSPSC Code:
12352200
PubChem Substance ID:
24278052
NACRES:
NA.77

product name

Nalbuphine hydrochloride hydrate, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble
ethanol: soluble

originator

Abbott

SMILES string

Cl[H].[H]O[H].[H][C@@]12Oc3c(O)ccc4C[C@H]5N(CC[C@@]1(c34)[C@@]5(O)CC[C@@H]2O)CC6CCC6

InChI

1S/C21H27NO4.ClH.H2O/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12;;/h4-5,12,15-16,19,23-25H,1-3,6-11H2;1H;1H2/t15-,16+,19-,20-,21+;;/m0../s1

Inchi Key

IUGXDRGXUYNFHK-XSFMULHUSA-N

Gene Information

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)

General description

Nalbuphine functions as an analgesic. It has anti catabolic properties. Nalbuphine maybe associated with sedation, nausea and vomiting.

Biochem/physiol Actions

Partial agonist for μ and κ opioid receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Three cases of nalbuphine hydrochloride dependence associated with anabolic steroid use.
McBride AJ, et al.
British Journal of Sports Medicine, 30(1), 69-70 (1996)
L R Gerak et al.
The Journal of pharmacology and experimental therapeutics, 276(2), 523-531 (1996-02-01)
Three rhesus monkeys discriminated between 0.178 mg/kg of nalbuphine and saline while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Nalbuphine produced dose-related increases in drug-lever responding with > or = 90% of responses occurring on the drug lever
Evaluation of nalbuphine hydrochloride
Miller RR
American Journal of Health-System Pharmacy, 37(7), 942-949 (1980)
Nalbuphine
Schmidt WK, et al.
Drug and Alcohol Dependence, 14(3-4), 339-362 (1985)
P J Emmerson et al.
Journal of neurochemistry, 73(1), 289-300 (1999-07-01)
The influence of membrane microviscosity on mu-opioid agonist and antagonist binding, as well as agonist efficacy, was examined in membranes prepared from SH-SY5Y cells and from a C6 glioma cell line stably expressing the rat mu-opioid receptor (C6mu). Addition of
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