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Key Documents

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M9948

Sigma-Aldrich

Mirin

≥98% (HPLC), powder

Sinónimos:

5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one

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About This Item

Fórmula empírica (notación de Hill):
C10H8N2O2S
Número de CAS:
299953-00-7
Peso molecular:
220.25
MDL number:
MFCD05885480
UNSPSC Code:
12352200
PubChem Substance ID:
329818100
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

red to orange

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2

InChI

1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-

InChI key

YBHQCJILTOVLHD-YVMONPNESA-N

Gene Information

human ... MRE11A(4361)

Application

Mirin has been used:
  • as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
  • as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
  • in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Biochem/physiol Actions

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.
Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instability
Edwards TG, et al.
PLoS ONE, 8(10), e75406-e75406 (2013)
AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
Piscitello D, et al.
Oncogene, 37(4), 427-427 (2018)
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses
Edwards TG and Fisher C
Antiviral Research, 152(4), 68-75 (2018)
Ann Liza Piberger et al.
Nature communications, 11(1), 5863-5863 (2020-11-19)
Stalled replication forks can be restarted and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle. Bulky DNA adducts are important replication-blocking lesions, but it is unknown whether they activate HR
Atsushi Shibata et al.
Molecular cell, 53(1), 7-18 (2013-12-10)
MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic. Here, we employed structure-based design
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