M1508
4-Methylumbelliferone sodium salt
fluorogenic, ≥98% (HPLC), crystalline
Sinónimos:
β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
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About This Item
Fórmula lineal:
C10H7O3Na
Número de CAS:
Peso molecular:
198.15
Número CE:
Número MDL:
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
NACRES:
NA.32
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Nombre del producto
4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
crystalline
color
yellow
solubilidad
water: 50 mg/mL
cadena SMILES
[Na+].CC1=CC(=O)Oc2cc([O-])ccc12
InChI
1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
Clave InChI
JGMQHDNPUCPRQE-UHFFFAOYSA-M
Descripción general
4-methylumbelliferone (4-MU) is a coumarin derivative.[1]
Aplicación
4-Methylumbelliferone sodium salt has been used:
- as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver[2]
- as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action[3]
- in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer[4]
Acciones bioquímicas o fisiológicas
4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic[5], and antitumor properties.[1] 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response.[5] 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.[2]
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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