L8000

L-Leucine

≥98% (HPLC), suitable for ligand binding assays

• Sinónimos: (S)-2-Amino-4-methylpentanoic acid
• Fórmula lineal: (CH₃)₂CHCH₂CH(NH₂)CO₂H
• Número de CAS: 61-90-5
• Peso molecular: 131.17
• Beilstein/REAXYS Number: 1721722
• EC Number: 200-522-0
• MDL number: MFCD00002617
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24896488
• NACRES: NA.26

Propiedades

• product name: L-Leucine, reagent grade, ≥98% (HPLC)
• grade: reagent grade
• assay: ≥98% (HPLC)
• form: powder
• technique(s): ligand binding assay: suitable
• impurities: isoleucine and methionine, essentially free
• color: white to off-white
• mp: >300 °C (lit.)
• application(s): peptide synthesis
• SMILES string: CC(C)C[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
• InChI key: ROHFNLRQFUQHCH-YFKPBYRVSA-N

Descripción

Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)