L1170

LY-487379 hydrochloride

≥98% (HPLC)

• Sinónimos: N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine hydrochloride
• Fórmula empírica (notación de Hill): C₂₁H₁₉F₃N₂O₄SHCl
• Número de CAS: 353229-59-1
• Peso molecular: 488.91
• MDL number: MFCD11519970
• UNSPSC Code: 12352209
• PubChem Substance ID: 329817387

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: off-white
• solubility: DMSO: >20 mg/mL
• originator: Eli Lilly
• storage temp.: 2-8°C
• SMILES string: Cl.COc1ccccc1Oc2ccc(cc2)N(Cc3cccnc3)S(=O)(=O)CC(F)(F)F
• InChI: 1S/C21H19F3N2O4S.ClH/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24;/h2-13H,14-15H2,1H3;1H
• InChI key: LPWFRDWTOKLHJC-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC₅₀ = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable