K2389

Ácido kaínico monohydrate

≥98% (HPLC), from Digenea simplex

• Sinónimos: 2-Carboxi-3-carboximetil-4-isopropenilpirrolidina
• Fórmula empírica (notación de Hill): C₁₀H₁₅NO₄ · H₂O
• Número de CAS: 58002-62-3
• Peso molecular: 231.25
• MDL number: MFCD00150833
• UNSPSC Code: 12352106
• PubChem Substance ID: 24724520
• NACRES: NA.77

Propiedades

• biological source: Digenea simplex
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
• InChI key: FZNZRJRSYLQHLT-SLGZUKMRSA-N

Descripción

Application

Kainic acid monohydrate has been used:

• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

Biochem/physiol Actions

El ácido kaínico monohidratado es un agonista de la clase kainato de los receptores ionotrópicos del glutamato, que induce convulsiones y neurodegeneración in vivo y se utiliza para inducir epilepsia experimental en roedores y para estudiar los mecanismos de apoptosis neuronal inducida por excitación.

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)