This product has not been tested for solubility in DMSO. However, other sources suggest that this compound can be solubilized in DMSO at approximately 10 mg/mL. This information has not been validated.
I1656
Idarubicin hydrochloride
solid
Sinónimos:
(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, 4-Demethoxydaunorubicin hydrochloride, DMDR, IMI-30, Idamycin
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About This Item
Fórmula empírica (notación de Hill):
C26H27NO9 · HCl
Número de CAS:
Peso molecular:
533.95
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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Formulario
solid
Nivel de calidad
emisor
Johnson & Johnson
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
cadena SMILES
[H][C@@]1(C[C@@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O)O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5
InChI
1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
Clave InChI
XDXDZDZNSLXDNA-TZNDIEGXSA-N
Información sobre el gen
human ... TOP2A(7153)
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Aplicación
Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
Acciones bioquímicas o fisiológicas
Topoisomerase II inhibitor
Características y beneficios
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 2 Oral - Carc. 2 - Repr. 1B
Código de clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Certificados de análisis (COA)
Lot/Batch Number
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Artículos
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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Is this soluble in DMSO, if yes then what conc.?
1 answer-
Helpful?
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What is the mode of action for idarubicin?
1 answer-
Idarubicin is an intercalating analog of daunorubicin that interferes with nucleic acid synthesis. It is an anti-tumor antibiotic used in the treatment of leukemia.
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How is idarubicin used therapeutically?
1 answer-
Idarubicin is an antineoplastic drug used to treat AML (Acute Myeloid Leukemia). In addition this compound has also been used in the treatment of breast cancer, non-Hodgkin's lymphoma, and both acute nonlymphocytic and chronic myelogenous leukemias.
Helpful?
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What can be used to make a solution of Idarubicin hydrochloride, Product I1656?
1 answer-
We test the solubility of idarubicin hydrochloride at 20 mg/ml of methanol. Idarubicin hydrochloride is also slightly soluble in water (10 mg/ml water with slight heat) and slightly soluble in ethanol.
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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