H9034
Hepatitis C virus core antigen
~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli
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recombinante
expressed in E. coli
Nivel de calidad
Ensayo
≥95% (SDS-PAGE)
mol peso
22 kDa (plus 114 kDa galactosidse)
concentración
~1 mg/mL
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Información sobre el gen
hepatitis C virus ... HCVgp1(951475)
human ... HBVgp4(944568)
Descripción general
Hepatitis C virus core antigen (HCV-cAg) is a well-preserved antigenic protein of the internal capsid.[1]
Hepatitis C virus glycoprotein 1 (HCVgp1), also referred to as polyprotein, is crucial for the induction of double-membrane vesicles, sites of HCV RNA amplification. The amino terminal of polyprotein contains the structural proteins core, envelope protein 1 (E1) and E2.[2] The proteolytic cleavage of polyprotein results in the formation of 10 mature viral proteins which are needed for viral replication and assembly.[3]
amino acids 2-192 of HCV polyprotein
Especificidad
Reacts strongly with human HCV positive serum.
Aplicación
Hepatitis core antigen (HCA) has been used as an analyte in enzyme-linked immunosorbent assay (ELISA) to study the mechanism of bovine serum albumin (BSA) blocking in common ELISA protocols.[4]
Acciones bioquímicas o fisiológicas
Hepatitis C virus core antigen (HCV-cAg) may be a less expensive way to diagnose active hepatitis C virus (HCV) infection in the hemodialysis (HD) population.[5]
Positive control for HCV antibodies.
Otras notas
HCV core antigen [2-192]-Galactosidase-tagged at the N-terminus.
Forma física
Solution in 8 M Urea, 20 mM Tris-HCl, pH 8.0, 10 mM 2-mercaptoethanol.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Xue Zheng Wong et al.
BMC nephrology, 21(1), 480-480 (2020-11-15)
Hepatitis C virus (HCV) infects more than 71 million people worldwide and chronic HCV infection increases the risk of liver cirrhosis and failure. Haemodialysis (HD) is one of the renal replacement therapies with risk of HCV transmission. Anti-HCV antibodies are
Alejandra Pérez-García et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 89, 131-136 (2019-10-04)
New efficient strategies are needed for the assessment of active hepatitis C virus (HCV) infection. The aim of this study was to evaluate the ability of HCV core antigen (HCV-cAg) as a marker of active HCV infection in newly diagnosed
BSA blocking in enzyme-linked immunosorbent assays is a non-mandatory step: a perspective study on mechanism of BSA blocking in common ELISA protocols
Ahirwar R, et al.
Royal Society of Chemistry Advances, 5(121), 100077-100083 (2015)
Margaret A Scull et al.
PLoS pathogens, 11(11), e1005297-e1005297 (2015-11-21)
The hepatitis C virus (HCV) p7 protein is required for infectious virus production via its role in assembly and ion channel activity. Although NMR structures of p7 have been reported, the location of secondary structural elements and orientation of the
Inés Romero-Brey et al.
mBio, 6(4), e00759-e00759 (2015-07-15)
Induction of membrane rearrangements in the cytoplasm of infected cells is a hallmark of positive-strand RNA viruses. These altered membranes serve as scaffolds for the assembly of viral replication factories (RFs). We have recently shown that hepatitis C virus (HCV)
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