H4381

6-Hydroxydopamine hydrochloride

≥97% (titration), powder, neurotoxin

• Sinónimos: 2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA
• Fórmula lineal: (HO)₃C₆H₂CH₂CH₂NH₂ · HCl
• Número de CAS: 28094-15-7
• Peso molecular: 205.64
• Beilstein: 4274007
• Número CE: 248-837-2
• Número MDL: MFCD00012895
• Código UNSPSC: 12352116
• ID de la sustancia en PubChem: 24895641
• NACRES: NA.77

Propiedades

• Nombre del producto: 6-Hydroxydopamine hydrochloride, ≥97% (titration), powder
• Nivel de calidad: 100
• Ensayo: ≥97% (titration)
• Formulario: powder
• color: off-white to brown
• mp: 232-233 °C (dec.) (lit.)
• solubilidad: H₂O: >50 mg/mL, clear, yellow to brown
• temp. de almacenamiento: room temp
• cadena SMILES: Cl.NCCc1cc(O)c(O)cc1O
• InChI: 1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
• Clave InChI: QLMRJHFAGVFUAC-UHFFFAOYSA-N

Descripción

Descripción general

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death.[1][2] 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.[2]

Aplicación

6-hydroxydopamine hydrochloride has been used:

• to induce Parkinson′s disease (PD) in rats[1]
• to analyse cytotoxic effect of 6-OHDA on PC12 cell line[3]
• to induce noradrenergic (NA) neuron deletion from the locus-coeruleus[2]

Acciones bioquímicas o fisiológicas

Neurotoxin that destroys catecholaminergic terminals.

Precaución

Hygroscopic

Reconstitución

Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.

Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves