GW22461F
Anti-Interleukin-2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
chicken
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
rat, mouse, human
fabricante / nombre comercial
Genway 15-288-22461F
técnicas
indirect ELISA: suitable
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... IL2(3558)
Descripción general
IL2 (interleukin 2) is a pro-inflammatory cytokine, which is predominantly synthesized by activated T-cells and dendritic cells (DCs). T-cells also act as effector of IL-2 as they contain the interleukin 2 receptor (IL2R). This gene is localized to human chromosome 4q27, and codes for a glycoprotein with a molecular weight of 14-17kDa.
Aplicación
Anti-Interleukin-2 antibody produced in chicken is suitable for the production of anti-IL2 surface-conjugated microtoroids. It is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Acciones bioquímicas o fisiológicas
Interleukin 2 (IL-2) is an interleukin and is a cytokine signaling molecule in the immune system. It plays an important role in signal transduction for biological functions of IL-2. Upregulation of IL-2 combined with activation of IL-2-dependent signaling pathways may contribute to the pathogenesis of Focal cortical dysplasia (FCD). Aerosol interleukin-2 (IL-2) increases the number of intravenously injected human natural killer (NK) cells in the lungs by stimulating local NK cell proliferation. The effect on NK cell proliferation is organ specific, which makes it ideal for the specific targeting of lung metastasis.
Forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Hunter A Martinez et al.
Nature communications, 15(1), 1564-1564 (2024-02-21)
Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that
Wei Guo et al.
Journal of neuropathology and experimental neurology, 73(3), 206-222 (2014-02-04)
Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role of the inflammatory cytokine interleukin 2 (IL-2) in the pathogenesis of FCD, we investigated the expression patterns of IL-2 and its receptors (IL-2Rs)
Marta Fichna et al.
Molecular biology reports, 40(12), 6957-6963 (2013-10-25)
Polymorphic variants at the interleukin-2 (IL2) locus affect the risk of several autoimmune disorders. Our aim was to evaluate the association of the four IL2 polymorphisms (rs6822844, rs6534349, rs2069762 and rs3136534) with type 1 diabetes (T1D) in the Polish population
Agata Kosmaczewska
International journal of molecular sciences, 15(10), 18574-18592 (2014-10-17)
For many years, the role of interleukin-2 (IL-2) in autoimmune responses was established as a cytokine possessing strong pro-inflammatory activity. Studies of the past few years have changed our knowledge on IL-2 in autoimmune chronic inflammation, suggesting its protective role
Marcel Joly et al.
Journal of theoretical biology, 335, 57-78 (2013-06-29)
In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4(+) T-lymphocytes from the G1
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