GS60
GST A1-1, Recombinant Human
Sinónimos:
GST-epsilon, GST2, GSTA1-1, GTH1, glutathione S-transferase alpha 1
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.26
Productos recomendados
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
frozen liquid
specific activity
21.04 units/mg protein
mol wt
23 kDa
concentration
2.0 mg/mL
storage temp.
−70°C
Gene Information
human ... GSTA1(2938)
General description
using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.
Biochem/physiol Actions
Glutathione S-transferase alpha 1 (GSTA1) is an enzyme that in humans is encoded by the GSTA1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
The GSTA1 gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
Storage and Stability
The enzyme should be used by the end-user customer within 1 year of receipt.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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