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Merck

D2197

Sigma-Aldrich

Diaphorase from Clostridium kluyveri

recombinant, expressed in E. coli, Animal-component free

Sinónimos:

Diaphorase, Lipoamide Dehydrogenase, Lipoyl Dehydrogenase

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About This Item

Comisión internacional de enzimas:
Código UNSPSC:
12352204
NACRES:
NA.54

recombinante

expressed in E. coli

Nivel de calidad

Formulario

solid

actividad específica

>=30 units/mg protein (biuret)

temp. de almacenamiento

−20°C

Descripción general

Research area: Cancer

Aplicación

Diaphorase from Clostridium kluyveri has been used:
  • in lactate dehydrogenase assay in gill cells.
  • impregnated on the strip for formate dehydrogenase assay.
  • in various assays to oxidate β-NADH or β-NADPH in the presence of an electron acceptor.
  • for semiquinone generation during benzoquinone reduction.
  • for evaluation of glucose uptake in cultured muscle cells.
  • in lactate dehydrogenase cytotoxicity assay.

Acciones bioquímicas o fisiológicas

Diaphorase catalyzes the oxidation of either β-NADH or β-NADPH in the presence of an electron acceptor such as methylene blue or 2,6-dichlorophenolindophenol. Diaphorases that are specific for either β-NADH or β-NADPH are known. The pig heart enzyme of Straub seems to have native diaphorase (β-NADH specific) as well as lipoic and lipoamide dehydrogenase activities.

Definición de unidad

One unit of diaphorase will oxidize 1.0 micromole of beta-NADH per minute at pH 7.5 at 25 degrees C, with the corresponding reduction of the appropriate electron acceptor.

Forma física

Supplied as a lyophilized powder containing trehalose.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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