CG5

Chorionic gonadotropin human

lyophilized powder, vial of ~5,000 IU

• Sinónimos: Choriogonin, HCG
• Número de CAS: 9002-61-3
• Número CE: 232-660-2
• Número MDL: MFCD00130797
• Código UNSPSC: 12352209
• NACRES: NA.32
• origen biológico: human urine
• Formulario: lyophilized powder

Propiedades

• origen biológico: human urine
• Nivel de calidad: 200
• esterilidad: sterile-filtered
• Formulario: lyophilized powder
• mol peso: 37.9 kDa
• contiene: mannitol
• envase: vial of ~5,000 IU
• drug control: Home Office Schedule 4.2
• impurezas: HBsAg, HCV and HIV-1/HIV-2, tested negative
• solubilidad: water: 10 mL/vial, clear to slightly hazy, colorless
• Nº de acceso UniProt: P01215
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... CGA(1081)

Descripción

Descripción general

Chorionic gonadotropin human (CGA or hCG) is a heterodimer and belongs to the cystine knot growth factor superfamily. It exists as six variants namely hCGn, hCGβ, hCGβn, hCGβcf and hCGα including hCG.[1] CGA is mapped to human chromosome 6q14.3.[2] hCG comprises of α and β chain.[3]

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Aplicación

Chorionic gonadotropin human has been used:

• to induce oocyte maturation in cultured follicles[4]
• along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice[5]
• as medium component for fetal testes culture to aid steroidogenic responsiveness[6]

Acciones bioquímicas o fisiológicas

Elevated levels of hCG is observed in trophoblastic cancer.[7] hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples.[8] hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.[3]

Reconstitución

When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.1 M sodium phosphate buffer (pH approx. 7.2) and 100 mg/mL of mannitol.

Nota de análisis

The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 5,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable