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C5874

Sigma-Aldrich

Cidofovir hydrate

≥98% (HPLC), powder, viral DNA synthesis inhibitor

Sinónimos:

(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, (S)-HPMPC; Cidovir, HPMPC, Vistide

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About This Item

Fórmula empírica (notación de Hill):
C8H14N3O6P · xH2O
Número de CAS:
113852-37-2
Peso molecular:
279.19 (anhydrous basis)
Número MDL:
MFCD17215968
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329775105
NACRES:
NA.77

Nombre del producto

Cidofovir hydrate, ≥98% (HPLC)

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

condiciones de almacenamiento

desiccated
protect from light

solubilidad

deionized water: ≥5 mg/mL (warmed)

temp. de almacenamiento

room temp

cadena SMILES

O.NC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1

InChI

1S/C8H14N3O6P.H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);1H2/t6-;/m0./s1

Clave InChI

KLJYJZIIJLYJNN-RGMNGODLSA-N

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Acciones bioquímicas o fisiológicas

Selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301,H315

Clasificaciones de peligro

Acute Tox. 3 Oral - Skin Irrit. 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000403275
0000403276
0000400544
0000390479
0000344686

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Michel Bossens et al.
International journal of clinical pharmacology and therapeutics, 56(3), 134-141 (2018-01-11)
The primary objective was to evaluate the safety and local tolerance of a topical 2% (w/w) cidofovir gel, applied directly to the cervices of women with high-grade cervical intraepithelial neoplasia (CIN 2+). The secondary objective was to evaluate the pharmacokinetics
Successful treatment of perianal giant condyloma acuminatum in an immunocompromised host with systemic interleukin 2 and topical cidofovir.
Vinod E Nambudiri et al.
JAMA dermatology, 149(9), 1068-1070 (2013-07-05)
Stephen D S McCarthy et al.
PLoS neglected tropical diseases, 10(1), e0004364-e0004364 (2016-01-12)
To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in vitro and/or in non-human primate studies, differences in experimental methodologies make it difficult
Erika Trompet et al.
Antiviral research, 182, 104901-104901 (2020-08-09)
Murine γ-herpesvirus-68 (MHV-68), genetically and biologically related to human γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus, can be easily propagated in vitro allowing drug resistance studies. Previously, we described specific changes in MHV-68 protein kinase (PK) or thymidine kinase (TK)
Joanna Jackowska et al.
Lasers in medical science, 34(7), 1433-1440 (2019-02-15)
Mechanical debulking of laryngeal papillomas is associated with voice disorders due to impairment of the vocal fold's mucosa. Intraepithelial injection of cidofovir reduces damage to the laryngeal structures and thus improves vocal parameters. The aim of our study was to
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