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Key Documents

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C4124

Sigma-Aldrich

Chromium picolinate

≥98% (HPLC)

Sinónimos:

Cr(pic)3, CrPic

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About This Item

Fórmula empírica (notación de Hill):
C18H12CrN3O6
Número de CAS:
14639-25-9
Peso molecular:
418.30
MDL number:
MFCD00068715
UNSPSC Code:
12352200
PubChem Substance ID:
329775054
NACRES:
NA.25

biological source

synthetic

Quality Level

100

assay

≥98% (HPLC)

form

powder

loss

≤5% loss on drying

storage temp.

room temp

SMILES string

O=C(O[Cr](OC(=O)c1ccccn1)OC(=O)c2ccccn2)c3ccccn3

InChI

1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3

InChI key

CBDQOLKNTOMMTL-UHFFFAOYSA-K

General description

Chromium picolinate is a supplemental or alternative medication for type 2 diabetes and an anti-diabetic mechanisms of CrPic in insulin-resistant 3T3-L1 adipocytes.

Application

Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.

Biochem/physiol Actions

Chromium picolinate (CrPic) is a supplemental or alternative medication for type 2 diabetes. Experimental evidence shows the effect of CrPic on glucose uptake through the activation of p38 MAPK. Chromium is thought to potentiate the action of insulin, leading to increased insulin sensitivity in type 2 diabetes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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C P A van de Ligt et al.
Journal of animal science, 80(2), 483-493 (2002-03-09)
Two experiments were conducted to evaluate potential interactive effects of supplemental Cr and dietary energy supply in growing pigs. Experiment 1 used 36 individually penned barrows, 25 to 65 kg, in a 2 x 3 factorial arrangement of supplemental Cr
G W Evans et al.
Journal of inorganic biochemistry, 49(3), 177-187 (1993-02-15)
Coordination complexes of chromium (Cr) and two pyridine carboxylate isomers, nicotinate (nic) and picolinate (pic) were synthesized and analyzed. Cr mono and dinicotinate complexes were formed with 1:1 and 1:2 ratios of Cr3+ and nic at pH 7.5. Cr dinicotinate
J C Woodworth et al.
Domestic animal endocrinology, 26(1), 1-9 (2004-01-21)
Thirty-four sows (parity=1.8; BW=206 kg) were used to determine the influence of L-carnitine and/or chromium tripicolinate on plasma leptin concentrations of gestating sows fed one meal daily. Treatments were arranged in a 2 x 2 factorial with main effects of
L D Bunting et al.
Journal of animal science, 72(6), 1591-1599 (1994-06-01)
Holstein calves, 10 steers (98 +/- 16 kg; Exp. 1) and 14 heifers (122 +/- 7 kg; Exp. 2), were fed either corn-cottonseed hull basal diets (CON; 15.1 and 13.2% CP, respectively) or CON plus 370 micrograms/kg of Cr as
C P A Van de Ligt et al.
Journal of animal science, 80(9), 2412-2419 (2002-09-28)
This study was conducted to evaluate potential interactive effects of supplemental Cr and dietary protein levels in growing pigs. Thirty-six individually penned barrows, 22 to 63 kg, were used in a 2 x 3 factorial arrangement of supplemental Cr (0
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