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Merck

C3167

Sigma-Aldrich

Corticotropin Releasing Factor sheep

≥95% (HPLC)

Sinónimos:

CRF, CRH

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About This Item

Fórmula empírica (notación de Hill):
C205H339N59O63S
Número de CAS:
Peso molecular:
4670.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

Quality Level

assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

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Amino Acid Sequence

Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2

Biochem/physiol Actions

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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L O E Ebbesson et al.
Journal of neuroendocrinology, 23(8), 733-741 (2011-05-20)
Salmon parr-smolt transformation (smoltification) is a mid-life transitional stage between life in freshwater and seawater that entails a wide range of neural, endocrine and physiological modifications. In salmon, the neuroendocrine corticotropin-releasing factor (CRF) system regulates pituitary adrenocorticotrophic hormone and thyrotrophin
Cun Li et al.
Endocrinology, 154(7), 2365-2373 (2013-04-30)
Intrauterine growth restriction (IUGR) is an important fetal developmental problem resulting from 2 broad causes: maternal undernutrition and/or decreased fetal nutrient delivery to the fetus via placental insufficiency. IUGR is often accompanied by up-regulation of the hypothalamo-pituitary-adrenal axis (HPAA). Sheep
Susan K Wood et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R940-R950 (2013-04-05)
Barrington's nucleus, in the pons, regulates micturition through spinal projections to preganglionic parasympathetic neurons. The stress neuropeptide CRF is prominent in these projections and has an inhibitory influence. Social stress in rats causes urinary retention and abnormal urodynamics resembling those
Yundong Sun et al.
Gastroenterology, 144(7), 1478-1487 (2013-03-09)
Stress alters brain-gut interactions and could exacerbate intestinal disorders, including irritable bowel syndrome. Alterations in the intestinal microbiota have been associated with irritable bowel syndrome. Maintenance of healthy microbiota requires nucleotide-binding oligomerization domain protein-like receptors, pyrin-domain containing (NLRP)-6 inflammasomes. We
Koro Gotoh et al.
Journal of neurochemistry, 125(4), 588-598 (2013-02-26)
Brain-derived neurotrophic factor (BDNF), corticotropin-releasing factor (CRF), and hypothalamic neuronal histamine are anorexigenic substances within the hypothalamus. This study examined the interactions among BDNF, CRF, and histamine during the regulation of feeding behavior in rodents. Food intake was measured after

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