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Key Documents

C1608

Sigma-Aldrich

Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse

clone C-1, ascites fluid, buffered aqueous solution

Sinónimos:

Anti-CRABP 1

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About This Item

MDL number:
MFCD02262690
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

C-1, monoclonal

form

buffered aqueous solution

mol wt

antigen 16 kDa

species reactivity

feline, turtle, monkey, rabbit, bovine, human, rat, chicken

should not react with

(chameleon), frog, goldfish

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P29762

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CRABP1(1381)
rat ... Crabp1(25061)

General description

Cellular retinoic acid-binding protein 1 is a protein encoded by the CRABP1 gene in humans. It encodes a specific binding protein for a vitamin A family member. It is also referred as RBP5, CRABP, CRABPI and CRABP-I.

Immunogen

performic acid oxidized CRABP 1, purified from bovine retina.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse is suitable for the following applications:
  • indirect ELISA
  • western blotting at a dilution of 1:1000
  • immunofluorescence at a working dilution of 1:250

Biochem/physiol Actions

Cellular retinoic acid-binding protein 1 (CRABP1) is a prognostic marker for adenocarcinoma and clear cell carcinoma that exhibits chemo-resistance. It is a is a modulator of retinoic acid and plays an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 also functions as a tumor-suppressor in esophageal epithelium and its epigenetic silencing may play a pivotal role during esophageal carcinogenesis.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yi-Chiung Hsu et al.
Molecular carcinogenesis, 62(12), 1935-1946 (2023-08-29)
Cellular retinoic acid binding protein 1 (CRABP1) participates in the regulation of retinoid signaling. Previous studies showed conflicting results regarding the role of CRABP1 in tumor biology, including protumorigenic and tumor-suppressive effects in different types of cancer. Our bioinformatics analyses
Yu-Lung Lin et al.
Endocrinology, 158(9), 3004-3014 (2017-09-16)
Retinoic acid (RA) is the active ingredient of vitamin A. It exerts its canonical activity by binding to nuclear RA receptors (RARs) to regulate gene expression. Increasingly, RA is also known to elicit nongenomic RAR-independent activities, most widely detected in
Sung Wook Park et al.
The Journal of endocrinology, 236(3), 151-165 (2018-01-27)
Excessive and/or persistent activation of calcium-calmodulin protein kinase II (CaMKII) is detrimental in acute and chronic cardiac injury. However, intrinsic regulators of CaMKII activity are poorly understood. We find that cellular retinoic acid-binding protein 1 (CRABP1) directly interacts with CaMKII
M W Kelley et al.
Development (Cambridge, England), 119(4), 1041-1053 (1993-12-01)
The mammalian organ of Corti has one of the most highly ordered patterns of cells in any vertebrate sensory epithelium. A single row of inner hair cells and three or four rows of outer hair cells extend along its length.
Shawna D Persaud et al.
Scientific reports, 6, 22396-22396 (2016-03-05)
All trans retinoic acid (atRA) is one of the most potent therapeutic agents, but extensive toxicity caused by nuclear RA receptors (RARs) limits its clinical application in treating cancer. AtRA also exerts non-genomic activities for which the mechanism remains poorly
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