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Merck
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Key Documents

AV36965

Sigma-Aldrich

Anti-PTRF antibody produced in rabbit

IgG fraction of antiserum

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

43 kDa

species reactivity

mouse, human

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... PTRF(19285)

General description

Polymerase I and transcript release factor (PTRF) contains a leucine zipper motif, a nuclear localization signal, and PEST domains. It is critically involved in termination of transcription by stalling RNA poly I and releasing it from the elongating transcript. PTRF is also found localized to caveolae and regulates formation of the vesicles at the plasma membrane.

Immunogen

Synthetic peptide directed towards the middle region of mouse PTRF

Biochem/physiol Actions

In mouse, pausing of elongation complexes is mediated by the transcription termination factor TTF-I bound to the ′Sal box′ terminator downstream of the rDNA transcription unit. PTRF is a Pol I and transcript release factor for dissociation of paused ternary complexes.

Sequence

Synthetic peptide located within the following region: SEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEESRAERIKRS

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Rahul Chadda et al.
Cell, 132(1), 23-24 (2008-01-15)
Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae
Stéphanie Torrino et al.
The Journal of cell biology, 217(12), 4092-4105 (2018-10-24)
Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer tension variations at the plasma membrane. Here we show that under mechanical stress, the EHD2 ATPase is rapidly released from caveolae, SUMOylated, and translocated to the nucleus, where
P Jansa et al.
The EMBO journal, 17(10), 2855-2864 (1998-06-10)
Termination of transcription by RNA polymerase I (Pol I) is a two-step process which involves pausing of elongating transcription complexes and release of both pre-rRNA and Pol I from the template. In mouse, pausing of elongation complexes is mediated by
Vikas A Tillu et al.
Molecular biology of the cell, 26(20), 3561-3569 (2015-08-14)
Caveolae are abundant surface organelles implicated in a range of cellular processes. Two classes of proteins work together to generate caveolae: integral membrane proteins termed caveolins and cytoplasmic coat proteins called cavins. Caveolae respond to membrane stress by releasing cavins
Kerrie-Ann McMahon et al.
eLife, 10 (2021-06-19)
Caveolae-associated protein 3 (cavin3) is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome using genome-edited cells together with label-free quantitative proteomics. These studies revealed a prominent role for cavin3 in DNA repair, with BRCA1 and BRCA1

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