A8381

L-Asparragina monohydrate

≥99% (TLC)

• Sinónimos: 4-Amida del ácido(S)-2-aminosuccínico, 4-Amida del ácido L-aspártico, Ácido (S)-(+)-2-aminosuccinámico
• Fórmula lineal: NH₂COCH₂CH(NH₂)COOH · H₂O
• Número de CAS: 5794-13-8
• Peso molecular: 150.13
• Beilstein/REAXYS Number: 1723527
• EC Number: 200-735-9
• MDL number: MFCD00151038
• UNSPSC Code: 12352209
• PubChem Substance ID: 24891338
• NACRES: NA.26

Propiedades

• product name: L-Asparragina monohydrate, ≥99% (TLC)
• biological source: synthetic
• assay: ≥99% (TLC)
• form: powder
• color: white to off-white
• mp: 233-235 °C (lit.)
• application(s): cell analysis; peptide synthesis
• SMILES string: [H]O[H].N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
• InChI key: RBMGJIZCEWRQES-DKWTVANSSA-N

Descripción

General description

Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues. Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt. It is also present in senescing leaves and germinating seeds.

Application

L-Asparagine monohydrate has been used:

• as a component of Sauton′s and chelated Sauton′s media for mycobacterial growth
• to test its effect in the induction of Ca²⁺ flux in rice roots using aequorin luminescence imaging
• as a component of fermentation medium for the Blakeslea trispora spores

Biochem/physiol Actions

Asparagine has high nitrogen to carbon ratio and is a key regulator for nitrogen storage and transport. Its thermal degradation in the presence of sugars leads to the acrylamide formation in foods. Asparagine serves as an amino acid exchange factor and is essential for amino acid homeostasis. It favors cancer cell proliferation.

L-Asparagine, a proteinogenic amino acid, is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies and in cell culture based research.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)