76548

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

≥97.0% (TLC)

• Sinónimos: (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine, 3-sn-Phosphatidylethanolamine, 1,2-dideoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE, Dioleoyl phosphatidylethanolamine, PE(18:1(9Z)/18:1(9Z))
• Fórmula empírica (notación de Hill): C₄₁H₇₈NO₈P
• Número de CAS: 4004-05-1
• Peso molecular: 744.03
• Beilstein/REAXYS Number: 1718431
• MDL number: MFCD00057986
• UNSPSC Code: 51191904
• PubChem Substance ID: 329767176
• NACRES: NA.85

Propiedades

• biological source: synthetic
• assay: ≥97.0% (TLC)
• form: solid
• functional group: amine
• lipid type: phosphoglycerides
• storage temp.: −20°C
• SMILES string: CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
• InChI: 1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-
• InChI key: MWRBNPKJOOWZPW-CLFAGFIQSA-N

Descripción

Application

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents .

Biochem/physiol Actions

DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)