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Key Documents

76546

Sigma-Aldrich

Lipase, immobilized on Immobead 150 from Thermomyces lanuginosus

≥3000 U/g

Sinónimos:

Immobilized lipase, Lipase enzyme

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54

biological source

fungus (Thermomyces lanuginosus)

form

powder (or beads)

specific activity

≥3000 U/g

technique(s)

analytical sample preparation: suitable

color

white to off-white

application(s)

life science and biopharma

storage temp.

2-8°C

General description

Research area: Cell Signaling

Lipase from Thermomyces lanuginosus (TLL) is a basophilic, single-chain protein and thermostable enzyme. It belongs to the alpha/beta-hydrolase fold family. TLL is roughly spherical and is made up of a central seven-stranded β-parallel sheet with five interconnecting α-helices.

Application

Lipase, immobilized on Immobead 150 from Thermomyces lanuginosus has been used:
  • as a biocatalyst to study ultrasound-assisted transesterification of a blend of non-edible oils with methanol.
  • as a catalyst in the synthesis of medium chain fatty acids (MCFA) and polyunsaturated fatty acids (PUFA) rich oils by enzymatic structuring of flax seed oil.
  • for the resolution of chiral compounds and the transesterification production of biodiesel.
  • to enhance the efficiency and selectivity of the enzymatic synthesis of ethyl-(R)-2-hydroxy-4-phenylbutyrate, (R)-HPB ester.
  • to facilitate a chemoenzymatic process for the continuous synthesis of (S)-7-((tert-Butyldiphenylsilyl)oxy)hept-1-yn-4-ol, a crucial intermediate for Eribulin synthesis, within a packed-bed reactor setup.

Biochem/physiol Actions

It participates in catalyzing the hydrolysis of triglycerides at the water-lipid interface and produces mono-, di-glycerides, and free fatty acids. Due to its versatility, this enzyme is applicable in various industries including, detergents, paper, leather, baking, fine chemicals, fuel, and biocatalysts.
Lipases catalyze the hydrolysis of triacylglycerols into glycerol and free fatty acids.

Unit Definition

1 U corresponds to the amount of enzyme which liberates 1 μmol butyric acid per minute at pH 7.5 and 40°C (tributyrin, Cat. No. 91010, as substrate)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Study of Thermomyces lanuginosa Lipase in the Presence of Tributyrylglycerol and Water
Santini S, et al.
Biophysical Journal, 96(12), 4814?4825-4814?4825 (2009)
Chemoenzymatic Process for the Preparation of (S)-7-((tert-Butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a Continuous Packed-Bed Reactor, a Key Intermediate for Eribulin Synthesis
Krishna AS, et al.
Organic Process Research & Development, 24(11), 2657?2664-2657?2664 (2020)
An improved process for the preparation of ethyl-(R)-2-hydroxy-4-phenylbutyrate, (R)-HPB ester by lipase from Thermomyces lanuginosus
Basetty S, et al.
bioresource technology reports, 101163-101163 (2022)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

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