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Documentos clave

490M-1

Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody

Sinónimos:

TYH

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About This Item

Código UNSPSC:
41116161

origen biológico

(Mouse)

Nivel de calidad

500

conjugado

unconjugated

forma del anticuerpo

(IgG1 Supernatant)

tipo de anticuerpo

primary antibodies

clon

LNC1

descripción

For In Vitro Diagnostic Use in Select Regions

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL (concentrate (490M-14))
vial of 0.1 mL (concentrate (490M-14-RUO) Research Use Only)
vial of 0.5 mL (concentrate (490M-15))
vial of 1.0 mL (concentrate (490M-16))
vial of 1.0 mL (concentrate (490M-16-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (490M-17-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (490M-17))
vial of 7.0 mL (pre-dilute ready-to-use (490M-18))
vial of 7.0 mL (pre-dilute ready-to-use (490M-18-RUO) Research Use Only)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

isotipo

IgG1

control

neuroblastoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic

Descripción general

Tyrosine Hydroxylase (TYH) is the rate-limiting enzyme of catecholamine biosynthesiss. TYH uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-DOPA, a precursor to dopamine. Anti-TYH is sensitive and specific for peripheral neuroblastic tumors in the differential diagnosis from other tumors of childhood and shows high diagnostic utility. Anti-TYH has been shown to positively label all pheochromocytomas and sympathetic paragangliomas, and thus aids in differentiating them from their histologic mimics such as adrenocortical neoplasms.

Calidad

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

Download the IFU specific to your product lot and format
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Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

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Lot/Batch Number

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Junkichi Takemoto et al.
Human pathology, 85, 162-167 (2018-11-24)
The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; 3 ganglioneuroblastomas
L A Loizou
British journal of pharmacology, 41(1), 41-48 (1971-01-01)
1. Tyrosine hydroxylase is thought to be the rate limiting enzyme step in catecholamine biosynthesis. Inhibition of this enzyme using alpha-methyl-p-tyrosine resulted in a time dependent depletion (and repletion) of formaldehyde induced fluorescence in catecholamine-containing neurones of the central nervous
Mikako Warren et al.
Histopathology, 72(4), 685-696 (2017-10-08)
This study evaluated the utility of Phox2b in paediatric tumours. Previously, tyrosine hydroxylase (TH) was the most widely utilised sympathoadrenal marker specific for neural crest tumours with neuronal/neuroendocrine differentiation. However, its sensitivity is insufficient. Recently Phox2b has emerged as another
S Colette Daubner et al.
Archives of biochemistry and biophysics, 508(1), 1-12 (2010-12-24)
Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. Modes of

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