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Y0000106

Pilocarpine nitrate for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Pilocarpine nitrate salt

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About This Item

Fórmula empírica (notación de Hill):
C11H16N2O2 · HNO3
Número de CAS:
148-72-1
Peso molecular:
271.27
Beilstein:
4171406
Número MDL:
MFCD00078497
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329830847
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

pilocarpine

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

Clave InChI

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Información sobre el gen

human ... CHRM1(1128) , CHRM3(1131)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Pilocarpine nitrate for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Nonselective muscarinic acetylcholine receptor agonist.
Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

P1650000

Pilocarpine hydrochloride, European Pharmacopoeia (EP) Reference Standard

P1700000

Pilocarpine nitrate, European Pharmacopoeia (EP) Reference Standard

PHR1494

Pilocarpine Nitrate, Pharmaceutical Secondary Standard; Certified Reference Material

1538902

Pilocarpine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1539009

Pilocarpine nitrate, United States Pharmacopeia (USP) Reference Standard

PHR1493

Pilocarpine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP503

Pilocarpine nitrate, British Pharmacopoeia (BP) Reference Standard

Pictogramas

Flame over circleSkull and crossbones
GHS03,GHS06

Palabra de señalización

Danger

Frases de peligro

H272,H302,H330

Clasificaciones de peligro

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Código de clase de almacenamiento

5.1B - Oxidizing hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Olav B Smeland et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1090-1097 (2013-04-25)
Although certain metabolic characteristics such as interictal glucose hypometabolism are well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear. Here, we performed a comprehensive study of brain metabolism in a mouse model of TLE, induced by pilocarpine-status
Linda Holtman et al.
Epilepsia, 54(4), 589-595 (2013-02-13)
Brain inflammation occurs during epileptogenesis and may contribute to the development and progression of temporal lobe epilepsy. Recently, several studies have indicated that seizures may also increase specific blood plasma cytokine levels in animal models as well as in human
Jay R Vargas et al.
Journal of neuropathology and experimental neurology, 72(10), 919-932 (2013-09-18)
Astrocytes have emerged as active participants of synaptic transmission and are increasingly implicated in neurologic disorders including epilepsy. Adult glial fibrillary acidic protein (GFAP)-positive hippocampal astrocytes are not known for ionotropic glutamate receptor expression under basal conditions. Using a chemoconvulsive
Shuo-Bin Jou et al.
Seizure, 22(3), 221-229 (2013-01-15)
Bilateral electrical stimulation of anterior nuclei of thalamus (ANT) has shown promising effects on epileptic seizures. However, bilateral implantation increases the risk of surgical complications and side effects. This study was undertaken to access the effectiveness of a stimulation paradigm
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
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