PHR8848

Cocaine hydrochloride

certified reference material, pharmaceutical secondary standard

• Sinónimos: Ecgonine methyl ester benzoate hydrochloride
• Fórmula empírica (notación de Hill): C₁₇H₂₁NO₄ · HCl
• Número de CAS: 53-21-4
• Peso molecular: 339.81
• MDL number: MFCD00058119
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material; pharmaceutical secondary standard
• agency: traceable to USP 1143008
• API family: cocaine
• application(s): pharmaceutical
• storage temp.: -10 to -25°C
• SMILES string: Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3
• InChI: 1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1
• InChI key: PIQVDUKEQYOJNR-VZXSFKIWSA-N

Descripción

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Información de seguridad

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H330,H336,H361d
• pcodes: P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable