PHR1764

Colchicina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: (S)-N-(5,6,7,9-Tetrahidro-1,2,3,10-tetrametoxi-9-oxobenzo[a]heptalen-7-il)acetamida
• Fórmula empírica (notación de Hill): C₂₂H₂₅NO₆
• Número de CAS: 64-86-8
• Peso molecular: 399.44
• Beilstein: 2228813
• Número CE: 200-598-5
• Número MDL: MFCD00078484
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823598
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 1150; traceable to Ph. Eur. C2580000; traceable to USP 1146006
• familia API: colchicine, thiocolchicoside
• CofA: current certificate can be downloaded
• envase: pkg of 400 mg
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 150-160 °C (dec.) (lit.)
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
• InChI: 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
• Clave InChI: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• Información sobre el gen: human ... TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)

Descripción

Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron).

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300,H340
• Consejos de prudencia: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral - Muta. 1B
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable