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PHR1078

Supelco

Vitamin K1

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Vitamin K1, Phytomenadione, 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K1(20)

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About This Item

Fórmula empírica (notación de Hill):
C31H46O2
Número de CAS:
84-80-0
Peso molecular:
450.70
Beilstein:
2568816
Número CE:
201-564-2
Número MDL:
MFCD00214063
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329823101
NACRES:
NA.24
En este momento no podemos mostrarle ni los precios ni la disponibilidad

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

300

Agency

traceable to BP 423
traceable to Ph. Eur. P1609000
traceable to USP 1538006

familia API

phytonadione

CofA

current certificate can be downloaded

condiciones de almacenamiento

protect from light

técnicas

HPLC: suitable
gas chromatography (GC): suitable

índice de refracción

n20/D 1.527 (lit.)

mp

−20 °C (lit.)

densidad

0.984 g/mL at 25 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

Clave InChI

MBWXNTAXLNYFJB-NKFFZRIASA-N

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Categorías relacionadas

Descripción general

Phytonadione belongs to the category of oral anticonvulsant drugs. It protects a newborn from acquiring hemorrhagic diseases by maintaining a normal blood clotting mechanism.[1][2]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Phytonadione may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic[3] and spectrophotometric techniques.[4]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB3714 in the slot below. This is an example certificate only and may not be the lot that you receive.

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Comparison of oral vs intravenous phytonadione (vitamin K1) in patients with excessive anticoagulation: a prospective randomized controlled study
Lubetsky A, et al.
Archives of Internal Medicine, 163(20), 2469-2473 (2003)
Development and validation of spectrophotometric methods fordetermination of phytomenadione in injection
Patel SA and Parikh PK
Current Research in Pharmaceutical Sciences, 39(17-18), 26-30 (2012)
NP-HPLC method for determining phytonadione and its impurities
Xue M, et al.
Journal of Liquid Chromatography and Related Technologies, 39(17-18), 799-805 (2016)
Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis
DeZee KJ, et al.
Archives of Internal Medicine, 166(4), 391-397 (2006)
Martin J Shearer et al.
Advances in nutrition (Bethesda, Md.), 3(2), 182-195 (2012-04-21)
In 2001, the US Food and Nutrition Board concluded that there were insufficient data with which to establish a RDA for vitamin K, in large part because of a lack of robust endpoints that reflected adequacy of intake. Knowledge of
Ver todos los artículos relacionados

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Could you clarify certified purity calculation for batch LRAD1021? CoA says 98.6% but I find 99.2% when using the formula and test results provided.

    1 answer

    1. The Loss On Drying (LOD) value is not provided on the Certificate of Analysis. This value was used in the final purity calculation to arrive at 98.6% the reported purity value. If not corrected for LOD, you will get a result of 99.2%.

      Helpful?

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