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Documentos clave

H0100100

Haloperidol decanoate

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Decanoic acid 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl ester

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About This Item

Fórmula empírica (notación de Hill):
C31H41ClFNO3
Número de CAS:
Peso molecular:
530.11
Código UNSPSC:
41116107
NACRES:
NA.24
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grado

pharmaceutical primary standard

familia API

haloperidol

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

Fc1ccc(cc1)C(=O)CCCN2CCC(CC2)(OC(=O)CCCCCCCCC)c3ccc(cc3)Cl

InChI

1S/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3

Clave InChI

GUTXTARXLVFHDK-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Haloperidol decanoate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

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Lucilene Cardoso et al.
Revista da Escola de Enfermagem da U S P, 43(1), 161-167 (2009-05-15)
Non-compliance with drug-based treatment is a complex and universal phenomenon that develops gradually during psychiatric treatments, and is related to disease aggravation. The purpose of this study was to describe the profile of using a given medication in the clientele
Resolution of tardive dyskinesia after addition of aripiprazole to haloperidol depot.
Joshua T Kantrowitz et al.
Journal of clinical psychopharmacology, 27(5), 525-526 (2007-09-18)
Matthew James Girgenti et al.
Journal of neurochemistry, 113(1), 175-187 (2010-01-15)
The molecular mechanism of action of antipsychotic drugs is not well understood. Their complex receptor affinity profiles indicate that their action could extend beyond dopamine receptor blockade. Single gene expression studies and high-throughput gene profiling have shown the induction of
Resolution of haloperidol-induced hyperprolactinemia with aripiprazole.
Raymond A Lorenz et al.
Journal of clinical psychopharmacology, 27(5), 524-525 (2007-09-18)
Delphine Charvin et al.
Neurobiology of disease, 29(1), 22-29 (2007-10-02)
Huntington's disease (HD) results from an abnormal polyglutamine extension in the N-terminal region of the huntingtin protein. This mutation causes preferential degeneration of striatal projection neurons. We previously demonstrated, in vitro, that dopaminergic D2 receptor stimulation acted synergistically with mutated

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