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Merck

G7776

Sigma-Aldrich

Glutaraldehyde solution

Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use

Sinónimos:

Glutaric dialdehyde solution, Pentane-1,5-dial

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About This Item

Fórmula lineal:
OHC(CH2)3CHO
Número de CAS:
Peso molecular:
100.12
Beilstein/REAXYS Number:
605390
MDL number:
UNSPSC Code:
12352114
PubChem Substance ID:
NACRES:
NA.21

Quality Level

type

Grade I

form

liquid

concentration

70% in H2O

technique(s)

electron microscopy: suitable (fixative)

color

colorless

solubility

water: soluble

storage temp.

−20°C

SMILES string

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

InChI key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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General description

Glutaraldehyde is a fixative used in electron microscopy. It is a rapidly penetrating fixative and an alternative to the expensive and toxic buffered osmium tetroxide. Glutaraldehyde contains two aldehyde group separated by three methylene bridges. It mediates protein crosslinking at their amino groups.

Application

Glutaraldehyde solution has been used as a fixative for transfected adherent monkey kidney fibroblasts (COS-7) cells for electron microscopy studies, human osteosarcoma (U2OS) cells for super-resolution (SR) experiments and for hydrogels for scanning electron microscopy (SEM) studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

supp_hazards

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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BRCA2 controls DNA: RNA hybrid level at DSBs by mediating RNase H2 recruitment
D?Alessandro G, et al.
Nature Communications, 9(1), 5376-5376 (2018)
Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: what they are and what they do
Kiernan JA
Microscopy today, 8(1), 8-13 (2000)
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy
Schessl J, et al.
The Journal of Clinical Investigation, 118(3), 904-912 (2008)
Poly (Ethylene Glycol)-Crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior
Su J, et al.
Biomaterials, 201(1), 99-112 (2019)
Ming Fang et al.
BMC neuroscience, 16, 84-84 (2015-11-27)
Scutellarin, an anti-inflammatory agent, effectively suppressed microglia activation in rats with middle cerebral artery occlusion (MCAO). Robust microglia activation, acute in onset, was followed by astrogliosis. This study was aimed to determine if scutellarin would also affect the reactive astrocytes

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