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Merck

C8037

Supelco

Clobetasol propionate

analytical standard

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About This Item

Fórmula empírica (notación de Hill):
C25H32ClFO5
Número de CAS:
Peso molecular:
466.97
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥98%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CCl

InChI

1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

InChI key

CBGUOGMQLZIXBE-XGQKBEPLSA-N

Gene Information

human ... NR3C1(2908)
rat ... Nr3c1(24413)

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General description

Clobetasol propionate is a novel and highly potent, topical corticosteroid, which is being assessed for its utility in the treatment of bullous pemphigoid.
Clobetasol propionate is a novel and highly potent, topical corticosteroid, which is being assessed for its utility in the treatment of bullous pemphigoid.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B - STOT RE 2

target_organs

Adrenal gland,Immune system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Certificados de análisis (COA)

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Treatment of bullous pemphigoid with topical clobetasol propionate
Westerhof W
Journal of the American Academy of Dermatology, 20, 458-461 (1989)
Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases
Lozada-Nur F, et al.
Oral Surgery, Oral Medicine, and Oral Pathology, 71, 283-287 (1991)
Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases.
Lozada-Nur F and Huang M Z
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 71(3), 283-287 (1991)
Treatment of bullous pemphigoid with topical clobetasol propionate.
Westerhof W.
Journal of the American Academy of Dermatology, 20(3), 458-461 (1989)
M Hofmann et al.
Archives of dermatological research, 305(3), 215-221 (2012-12-18)
Currently, there are no accurate and simple methods available to measure this risk of atrophy in patients treated with topical glucocorticosteroids. In the present clinical trial, we validated a new score (Dermaphot(®) score) to assess the atrophogenic potential of glucocorticosteroids.

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