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Key Documents

B0470000

Benperidol

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one

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About This Item

Fórmula empírica (notación de Hill):
C22H24FN3O2
Número de CAS:
2062-84-2
Peso molecular:
381.44
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

benperidol

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)

InChI key

FEBOTPHFXYHVPL-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benperidol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Certificados de análisis (COA)

Lot/Batch Number

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Complete dopamine D2 receptor occupancy without extrapyramidal side effects under benperidol.
Carlos Schönfeldt-Lecuona et al.
Journal of clinical psychopharmacology, 24(1), 97-98 (2004-01-08)
J Schröder et al.
Psychiatry research, 75(2), 115-123 (1997-11-14)
Recent studies have described a left lateralized striatal asymmetry of D2 dopamine receptors in male patients with schizophrenia. To replicate this finding and to explore its potential functional consequences, we investigated the D2 dopamine receptor system in 23 drug-naive patients
I Biryol et al.
Journal of pharmaceutical and biomedical analysis, 15(11), 1695-1701 (1997-07-01)
In this study two butyrophenones, droperidol and benperidol were voltammetrically investigated using platinum and specially activated glass carbon electrodes. The behaviours of the substance were investigated in various electrolyte solutions having different pH values and by different scan rates. As
J Schröder et al.
Fortschritte der Neurologie-Psychiatrie, 68 Suppl 1, S42-S45 (2000-07-25)
Animal and post mortem studies indicate that neuroleptic therapy may induce D2-dopamine receptor upregulation in the basal ganglia. To address this phenomenon in a clinical study, we investigated the D2-dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive state
Jo Ann V Antenor-Dorsey et al.
European journal of nuclear medicine and molecular imaging, 35(4), 771-778 (2007-12-12)
N-([(11)C]methyl)benperidol ([(11)C]NMB) can be used for positron emission tomography (PET) measurements of D(2)-like dopamine receptor binding in vivo. We report the absorbed radiation dosimetry of i.v.-administered (11)C-NMB, a critical step before applying this radioligand to imaging studies in humans. Whole-body
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