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Merck

90268

Sigma-Aldrich

Polyvinylpyrrolidone

K 25, tested according to Ph. Eur.

Sinónimos:

PVP, Polyvidone, Povidone

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About This Item

Fórmula lineal:
(C6H9NO)n
Número de CAS:
MDL number:
UNSPSC Code:
12352005
NACRES:
NA.21

agency

tested according to Ph. Eur.

form

powder

SMILES string

C=CN1CCCC1=O

InChI

1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2

InChI key

WHNWPMSKXPGLAX-UHFFFAOYSA-N

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Application


  • Colyophilized Sugar-Polymer Dispersions for Enhanced Processing and Storage Stability.: This study explores the use of polyvinylpyrrolidone in colyophilized sugar-polymer dispersions to improve the processing and storage stability of pharmaceuticals. The research demonstrates how combining sugars with polyvinylpyrrolidone enhances the physical stability and performance of the resulting dispersions, which is crucial for maintaining drug efficacy during storage and handling (Giannachi et al., 2024).

  • Fabrication and evaluation of stable amorphous polymer-drug composite particles via a nozzle-free ultrasonic nebulizer.: This article discusses the development of amorphous polymer-drug composite particles using polyvinylpyrrolidone and a nozzle-free ultrasonic nebulizer. The findings indicate that polyvinylpyrrolidone helps in stabilizing the amorphous form of the drug, which can enhance its solubility and bioavailability (Lee et al., 2024).

  • Polymer-Assisted Coprecipitation Synthesized Zinc Oxide Nanoparticles and Their Uses for Gre en Chemical Synthesis via Photocatalytic Glucose Conversions.: This study presents a novel method of using polyvinylpyrrolidone in the synthesis of zinc oxide nanoparticles. The research shows that these nanoparticles can be used in green chemical processes, such as the photocatalytic conversion of glucose, showcasing the versatility of polyvinylpyrrolidone in catalysis and material science (Kaewsaenee et al., 2023).

  • Development and evaluation of the in vitro schistosomicidal activity of solid dispersions based on 2-(-5-bromo-1-H-indole-3-yl-methylene)-N-(naphthalene-1-ylhydrazine-carbothiamide).: This article explores the use of polyvinylpyrrolidone in formulating solid dispersions for antiparasitic treatments. The findings demonstrate that polyvinylpyrrolidone can enhance the solubility and efficacy of the active pharmaceutical ingredient against parasitic infections (de Luna Rocha et al., 2024).

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Journal of hazardous materials, 299, 298-305 (2015-07-05)
The use of electrospun polyvinylpyrrolidone (PVP) nanofibers containing silver, copper, and zinc nanoparticles was studied to prepare antimicrobial mats using silver and copper nitrates and zinc acetate as precursors. Silver became reduced during electrospinning and formed nanoparticles of several tens
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Dalton transactions (Cambridge, England : 2003), 44(41), 17883-17905 (2015-10-06)
Colloidal synthesis offers a route to nanoparticles (NPs) with controlled composition and structural features. This Perspective describes the use of polyvinylpyrrolidone (PVP) to obtain such nanostructures. PVP can serve as a surface stabilizer, growth modifier, nanoparticle dispersant, and reducing agent.
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Solid dispersion technique has been developed many years for improving solubility of water-insoluble drugs, aiming to achieve a better oral bioavailability. However, this technique exhibits many inconveniences when used for large-scale tableting procedures. The objective of current research work was
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