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Merck

33818

Supelco

5-Hydroxythiabendazole

PESTANAL®, analytical standard

Sinónimos:

2-(4-Thiazolyl)-5-benzimidazolol, 5-Hydroxy-2-(4-thiazolyl)benzimidazole

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About This Item

Fórmula empírica (notación de Hill):
C10H7N3OS
Número de CAS:
Peso molecular:
217.25
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental
forensics and toxicology
veterinary

format

neat

SMILES string

Oc1ccc2[nH]c(nc2c1)-c3cscn3

InChI

1S/C10H7N3OS/c14-6-1-2-7-8(3-6)13-10(12-7)9-4-15-5-11-9/h1-5,14H,(H,12,13)

InChI key

VNENJHUOPQAPAT-UHFFFAOYSA-N

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General description

5-Hydroxythiabendazole present in excreta, eggs, edible tissues and milk is found to be the major metabolite of thiabendazole, an active ingredient in fungicidal preparations effective for plants. It can also be used as an anthelmintic drug, which is applicable both for humans and animals.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Thiabendazole and its metabolite 5-hydroxythiabendazole can undergo specific binding with monoclonal antibodies and can further undergo immobilization on agarose gels, which can find applications in immunoaffinity chromatography.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Los clientes también vieron

Immobilisation of thiabendazole specific antibodies on an agarose matrix for application in immunoaffinity chromatography
Horne E, et al.
Analyst, 124, 87-90 (1999)
S S Tai et al.
Journal - Association of Official Analytical Chemists, 73(3), 368-373 (1990-05-01)
The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (TBZ) from milk fortified at the 10
A Cannavan et al.
Journal of chromatography. B, Biomedical sciences and applications, 718(1), 103-113 (1998-12-01)
A novel method is presented for the determination of thiabendazole and 5-hydroxythiabendazole in animal tissues. Samples are homogenised in buffer at pH=7.0, extracted with ethyl acetate and cleaned up using CN solid-phase extraction columns. Thiabendazole and 5-hydroxythiabendazole are separated chromatographically
Metabolism of thiabendazole in laying hen and lactating goats
Chukwudebe.CA, et al.
Journal of Agricultural and Food Chemistry, 42, 2964-2969 (1994)
D Kerboeuf et al.
Veterinary parasitology, 93(1), 47-55 (2000-10-12)
Four groups of three lambs per group were experimentally infected with Cooperia curticei susceptible (two groups) or resistant (two groups) to benzimidazoles, and distributions of adult worms in the small intestine were studied. For each Cooperia isolate, one group was

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