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17929

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 5′000

Sinónimos:

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate

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About This Item

Fórmula lineal:
CH3O(CH2CH2O)nCOCH2CH2COOH
Número de CAS:
31961-02-1
MDL number:
MFCD00284260
UNSPSC Code:
51171641
NACRES:
NA.26

form

powder

Quality Level

100

mol wt

Mr ~5100

mp

56-60 °C

Ω-end

carboxylic acid

α-end

methoxy

storage temp.

−20°C

Application

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.
Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
063737/2
063737/2
2106A
63737/2
63737/1

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Poly(ethylene glycol) methyl ether average Mn 550

Sigma-Aldrich

202487

Poly(ethylene glycol) methyl ether

A Bogdanov et al.
Journal of drug targeting, 4(5), 321-330 (1997-01-01)
A co-polymer of O-methyl polyethylene(glycol)-O'-succinate (MPEGs, m.w. 5100) and poly-l-lysine (PL, median m.w. 32700, degree of polymerization 256) has been synthesized by covalent grafting. The resultant MPEGs-PL (30% modification degree of epsilon-amino groups) had a hydrodynamic diameter corresponding to a
Mario Beyer et al.
Methods in molecular biology (Clifton, N.J.), 570, 309-316 (2009-08-04)
Combinatorial synthesis of peptides on solid supports (1), either as spots on cellulose membranes (2) or with split-pool-libraries on polymer beads (3), substantially forwarded research in the field of peptide-protein interactions. Admittedly, these concepts have specific limitations, on one hand
Enhanced stability of PEG-block-poly(N-hexyl stearate l-aspartamide) micelles in the presence of serum proteins.
Diezi TA, Bae Y, Kwon GS.
Molecular Pharmacology, 7, 1355-1360 (2010)
Telli Hekmatara et al.
Journal of nanoscience and nanotechnology, 9(8), 5091-5098 (2009-11-26)
Hydrophobic drugs, loperamide and paclitaxel, were loaded in poly(butyl cyanoacrylate) nanoparticles by polymerization of n-butyl-2-cyanoacrylate in aqueous-organic media in the presence of a drug. The particles were stabilized by dextran 70,000 and poloxamer 188 or by 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] sodium salt.
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
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