04573

Tiamina hydrochloride

tested according to Ph. Eur.

• Sinónimos: Aneurina hydrochloride, Vitamina B₁ hydrochloride
• Fórmula empírica (notación de Hill): C₁₂H₁₇ClN₄OS · HCl
• Número de CAS: 67-03-8
• Peso molecular: 337.27
• Beilstein/REAXYS Number: 3851771
• EC Number: 200-641-8
• MDL number: MFCD00012780
• UNSPSC Code: 12352209
• eCl@ss: 34058006
• PubChem Substance ID: 329747946
• NACRES: NA.26

Propiedades

• biological source: synthetic
• Quality Level: 200
• agency: USP/NF; tested according to Ph. Eur.
• assay: 98.5-101.0% anhydrous basis
• form: solid
• mp: 250 °C (dec.) (lit.)
• solubility: alcohol: soluble 1 gm in 100 ml (95%); alcohol: soluble 1 gm in 315 ml (Absolute); glycerol: soluble 1 gm in 18 ml; water: soluble 1 g/mL; benzene: insoluble; chloroform: insoluble; diethyl ether: insoluble; hexane: insoluble; methanol: very soluble; propylene glycol: soluble
• storage temp.: 2-8°C
• SMILES string: CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
• InChI: 1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
• InChI key: DPJRMOMPQZCRJU-UHFFFAOYSA-M

Descripción

Application

Thiamine hydrochloride has been used as a keratin salts medium supplement for culturing log-phase fungus. It has also been used as a supplement of VB medium the minimal medium of Vogel and Bonner.

Biochem/physiol Actions

Thiamine hydrochloride is a cheap, non-toxic and efficient catalyst for the synthesis of amidoalkyl naphthols. It inhibits the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon. Additionally, thiamine hydrochloride addition to apple juice concentrates reduces its patulin content.

Thiamine hydrochloride is a hydrochloride salt form of thiamine (Vitamin B₁). It is crucial for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)