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MAB2168

Sigma-Aldrich

Anti-Huntingtin Disease (HD/HTT) Antibody

CHEMICON®, mouse monoclonal, HU-2E8

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Nombre del producto

Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8, ascites fluid, clone HU-2E8, Chemicon®

origen biológico

mouse

Nivel de calidad

100

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

HU-2E8, monoclonal

reactividad de especies

monkey, human

fabricante / nombre comercial

Chemicon®

técnicas

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotipo

IgG1

Nº de acceso NCBI

NM_002111.6

Nº de acceso UniProt

P42858

Condiciones de envío

dry ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... HTT(3064) , SLC6A4(6532)

Especificidad

Reacts with Huntingtin protein from human and monkey. Weak to no reactivity with mouse. Has not been tested on other species.

Inmunógeno

Epitope: a.a. 2146-2541
Human huntingtin fragment from aa 2146 to 2541 as a fusion protein.

Aplicación

Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8 is an antibody against Huntingtin Protein for use in ELISA, WB, IC, IH(P).
ELISA: 1:500-1:5,000

Western blot: 1:500-1:5,000

Immunohistochemistry on frozen and microwave oven treated paraffin sections

(human tissue): 1:500-1:5,000

Immunocytochemistry on transfected cells: 1:500-1:5,000

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

Forma física

Ascites fluid. Liquid, does not contain any preservative.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects.
Ciammola, A; Sassone, J; Alberti, L; Meola, G; Mancinelli, E; Russo, MA; Squitieri, F; Silani, V
Cell Death and Differentiation null
Wei Li et al.
The Journal of biological chemistry, 281(23), 15916-15922 (2006-04-06)
Huntington disease is an inherited neurodegenerative disorder that is caused by expanded CAG trinucleotide repeats, resulting in a polyglutamine stretch of >37 on the N terminus of the protein huntingtin (htt). htt is a large (347 kDa), ubiquitously expressed protein.
Ellen Sapp et al.
The Journal of biological chemistry, 287(16), 13487-13499 (2012-03-01)
Huntington disease (HD) is caused by polyglutamine expansion in the N terminus of huntingtin (htt). Analysis of human postmortem brain lysates by SDS-PAGE and Western blot reveals htt as full-length and fragmented. Here we used Blue Native PAGE (BNP) and
Hiroki Takano et al.
BMC neuroscience, 3, 15-15 (2002-10-16)
Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown inherent function. Huntingtin is moderately conserved, with 10
Amber L Southwell et al.
Human molecular genetics, 26(6), 1115-1132 (2017-01-21)
Huntington disease (HD) is a neurodegenerative disease caused by a mutation in the huntingtin (HTT) gene. HTT is a large protein, interacts with many partners and is involved in many cellular pathways, which are perturbed in HD. Therapies targeting HTT
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