AB6031

Anti-Integrin alpha-11 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Integrin alpha-11
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human
• reactividad de especies (predicha por homología): mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_001004439
• Nº de acceso UniProt: Q9UKX5
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: chicken ... Itga11(415560) ; human ... ITGA11(22801)

Descripción

Descripción general

Integrin alpha-11 (ITGA11) belongs to a family of cell adhesion molecules, which consist of noncovalent associated alpha-beta heterodimers, and is shown to be overexpressed in the stroma of human non-small-cell lung carcinomas (hNSCLCs). Upon dimerization, this protein is thought to enhance tumorgenicity of hNSCLCs by interacting with matrix collagen and stromal fibroblasts. Progesterone is shown to increase the expression of ITGA11 through mid-gestation and decrease thereafter in Sprague-Dawley rats. It is further indicated that MAPK signaling is associated with the regulation of these integrins.

Inmunógeno

Linear peptide corresponding to human Integrin alpha-11.

Aplicación

Anti-Integrin alpha-11 Antibody is an antibody against Integrin alpha-11 for use in WB.

Research Category
Cell Structure

Research Sub Category
Integrins

Calidad

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Integrin alpha-11 in 10 µg of non-boiled & non-B-ME HeLa cell lysate.

Descripción de destino

~135 kDa observed.
The high molecular weight band seen in a HeLa (non boiled) cell lysate is the integrin complex. The band at ~75-80 kDa is thought to be a denatured form of integrin.

Forma física

Affinity purified

Purified rabbit polyclonal containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Non-boiled & non-B-ME HeLa cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids