681673
Wnt Antagonist III, Box5
The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
Sinónimos:
Wnt Antagonist III, Box5, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
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About This Item
Fórmula empírica (notación de Hill):
C30H50N6O13S2
Peso molecular:
766.88
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥90% (HPLC)
Formulario
lyophilized solid
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
OK to freeze
protect from light
color
white
solubilidad
water: 4 mg/mL
DMSO: 50 mg/mL
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Descripción general
A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
Envase
Packaged under inert gas
Advertencia
Toxicity: Standard Handling (A)
Secuencia
t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
Reconstitución
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Otras notas
Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA106, 19473.
Safholm, A., et al. 2006. J. Biol. Chem.281, 2740.
Safholm, A., et al. 2006. J. Biol. Chem.281, 2740.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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