567727

D-erythro-Sphingosine-1-phosphate

A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway.

• Sinónimos: D-erythro-Sphingosine-1-phosphate
• Fórmula empírica (notación de Hill): C₁₈H₃₈NO₅P
• Número de CAS: 26993-30-6
• Peso molecular: 379.47
• Número MDL: MFCD00270077
• Código UNSPSC: 12352211
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (TLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: methanol: 0.5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: [P](=O)(OC[C@H](N)[C@H](O)\C=C\CCCCCCCCCCCCC)(O)O
• InChI: 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
• Clave InChI: DUYSYHSSBDVJSM-KRWOKUGFSA-N

Descripción

Descripción general

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃-independent pathway. Activates phospholipase D (PLD) and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss/3T3 fibroblasts. Inhibits activation of caspases that cleave PARP and lamins during Fas- and ceramide-mediated apoptosis.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Mobilizes calcium from intracellular stores

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Nota de preparación

Slight warming and vortexing may be required.

Reconstitución

Following reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20°C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20°C.

Otras notas

Cuvillier, O., et al. 1998. J. Biol. Chem. 273, 2910.
Mattie, M., et al. 1994. J. Biol. Chem.269, 3181.
Olivera, A. and Spiegel, S. 1993. Nature365, 557.
Desai, N.N., et al. 1992. J. Biol. Chem.267, 23122.
Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 9686.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable