A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
Acciones bioquímicas o fisiológicas
Cell permeable: no
Primary Target broad range protease
Product does not compete with ATP.
Reversible: no
Advertencia
Toxicity: Standard Handling (A)
Forma física
Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
Otras notas
Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236. Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919. Boisset, N., et al. 1992. J. Struct. Biol.108, 221. Barrett, A.J. 1980. Methods Enzymol.80, 737.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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