211200

CAPE

A cell-permeable active component of propolis from honeybee hives.

• Sinónimos: CAPE, Caffeic Acid Phenethyl Ester, Synthetic
• Fórmula empírica (notación de Hill): C₁₇H₁₆O₄
• Número de CAS: 104594-70-9
• Peso molecular: 284.31
• Número MDL: MFCD00866470
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white to off-white
• solubilidad: DMSO: 200 mg/mL; ethanol: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: O(CCc2ccccc2)C(=O)\C=C\c1cc(c(cc1)O)O
• InChI: 1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
• Clave InChI: SWUARLUWKZWEBQ-VQHVLOKHSA-N

Descripción

Descripción general

A cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK), and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
HIV-integrase

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Nicklaus, M.C., et al. 1997. J. Med. Chem.40, 920.
Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 9090.
Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2399.
Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable