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Merck
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Documentos clave

05-675

Sigma-Aldrich

Anti-Myelin Basic Protein Antibody

UPSTATE®, mouse monoclonal, SKB3

Sinónimos:

Anti-C76307, Anti-Hmbpr, Anti-R75289, Anti-golli-mbp, Anti-jve, Anti-mld, Anti-shi

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Nombre del producto

Anti-MBP Antibody, clone SKB3, clone SKB3, Upstate®, from mouse

origen biológico

mouse

Nivel de calidad

100

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

SKB3, monoclonal

reactividad de especies

rat, human, mouse

fabricante / nombre comercial

Upstate®

técnicas

western blot: suitable

isotipo

IgG1κ

Nº de acceso NCBI

NM_002385

Nº de acceso UniProt

P02686

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)

Especificidad

Recognizes MBP.

Inmunógeno

Peptide corresponding to the human myelin basic protein sequence containing amino acid Thr98

Aplicación

Detect MBP using this Anti-MBP Antibody, clone SKB3 validated for use in WB.
Research Category
Signaling
Research Sub Category
MAP Kinases

Calidad

routinely evaluated by immunoblot on RIPA lysates from mouse and rat brain tissue preparations

Descripción de destino

18-20 kDa

Forma física

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.02M Phosphate Buffer, 0.25 M NaCl, pH 7.6 with 15 mg/mL BSA containing no preservatives.

Almacenamiento y estabilidad

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Nota de análisis

Control
Brain tissue

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Monica Giannotta et al.
EMBO molecular medicine, 6(2), 239-258 (2014-01-01)
Muscular dystrophies are severe genetic diseases for which no efficacious therapies exist. Experimental clinical treatments include intra-arterial administration of vessel-associated stem cells, called mesoangioblasts (MABs). However, one of the limitations of this approach is the relatively low number of cells
Samantha K Barton et al.
Frontiers in neuroscience, 15, 705306-705306 (2021-09-21)
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but the extent to which this affects myelination
Robert Sparks et al.
The Journal of biological chemistry, 294(41), 14896-14910 (2019-08-16)
The metabolic consequences and sequelae of obesity promote life-threatening morbidities. PKCδI is an important elicitor of inflammation and apoptosis in adipocytes. Here we report increased PKCδI activation via release of its catalytic domain concurrent with increased expression of proinflammatory cytokines
Bangfu Zhu et al.
International journal of molecular sciences, 17(11) (2016-11-24)
The guided migration of neural cells is essential for repair in the central nervous system (CNS). Oligodendrocyte progenitor cells (OPCs) will normally migrate towards an injury site to re-sheath demyelinated axons; however the mechanisms underlying this process are not well
Cyclic AMP decreases the phosphorylation state of myelin basic proteins in rat brain cell cultures.
Ulmer, J B, et al.
The Journal of Biological Chemistry, 262, 1748-1755 (1987)
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