860065P

Ganglioside GM1 (Ovine Brain)

Avanti Research^™ - A Croda Brand

• Sinónimos: 110952
• Número de CAS: 37758-47-7
• Número MDL: MFCD00466936
• Código UNSPSC: 12352211
• NACRES: NA.25

Propiedades

• descripción: GM1 Ganglioside (Brain, Ovine-Sodium Salt)
• Ensayo: >99% (TLC)
• Formulario: powder
• envase: pkg of 1 × 1 mg (860065P-1mg); pkg of 1 × 10 mg (860065P-10mg); pkg of 1 × 25 mg (860065P-25mg); pkg of 1 × 5 mg (860065P-5mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand
• tipo de lípido: sphingolipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O[C@@H]4O[C@H](CO)[C@@H]([C@H](O[C@@H]5O[C@H
• InChI: 1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1
• Clave InChI: CNLVNZJJSHZYAS-ALSOZVJRSA-N

Descripción

Descripción general

Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain. Ganglioside GM1 has five glycosyl units.

Aplicación

Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies. It has also been used in liposome preparation for circular dichroism studies with human wild type−synuclein. It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis.

Acciones bioquímicas o fisiológicas

Ganglioside GM1 is a modulator of Ca²⁺ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.

Envase

5 mL Amber Glass Screw Cap Vial (860065P-10mg)

5 mL Amber Glass Screw Cap Vial (860065P-1mg)

5 mL Amber Glass Screw Cap Vial (860065P-25mg)

5 mL Amber Glass Screw Cap Vial (860065P-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable