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850356C

Avanti

4ME 16:0 PC

Avanti Research™ - A Croda Brand

Sinónimos:

1,2-di-(3,7,11,15-tetramethylhexadecanoyl)-sn-glycero-3-phosphocholine; PC(16:0(3me,7me,11me,15me)/16:0(3me,7me,11me,15me))

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About This Item

Fórmula empírica (notación de Hill):
C48H96NO8P
Número de CAS:
207131-40-6
Peso molecular:
846.25
MDL number:
MFCD00674308
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-diphytanoyl-sn-glycero-3-phosphocholine, chloroform

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850356C-25mg)
pkg of 1 × 20 mL (850356C-500mg)
pkg of 2 × 4 mL (850356C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (850356C-25mg)
25 mg/mL (850356C-200mg)
25 mg/mL (850356C-500mg)

shipped in

dry ice

storage temp.

−20°C

Categorías relacionadas

General description

4ME 16:0 PC/DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine is a synthetic lipid. It has ester linkages between acyl chains and glycerol backbone and also between the headgroup and glycerol backbone. This neutral lipids possess high steric asymmetry. It remains in fluid or viscous liquid crystalline state over a wide range of temperature.
Lipids containing diphytanoyl fatty acid chains have been used to produce stable planar lipid membranes (see References). Diphytanoyl phosphatidylcholine does not exhibit a detectable gel to liquid crystalline phase transition from -120°C to +120°C.The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis.

Application

4ME 16:0 PC is suitable for use:
  • to study its phase behaviour and its interactions with the representative antimicrobial peptide PGLa from Xenopus laevis (peptidyl-glycylleucine-carboxyamide
  • to improve the mechanical stability of planar lipid bilayer membrane
  • to prepare giant unilamellar vesicles (GUVs)

Biochem/physiol Actions

4ME 16:0 PC/DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine can be used as a bilayer mimic for electrophysiological measurements. It is stable under mechanical stress but the ester linkages are liable to hydrolysis under acidic or alkaline conditions.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850356C-500mg)
5 mL Clear Glass Sealed Ampule (850356C-200mg)
5 mL Clear Glass Sealed Ampule (850356C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Referencia del producto
Descripción
Precios

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Formation and characterization of planar lipid bilayer membranes from synthetic phytanyl-chained glycolipids
Baba T, et al.
Biochimica et Biophysica Acta - Biomembranes, 1421(1), 91-102 (1999)
Patrick Urban et al.
Langmuir : the ACS journal of surfaces and colloids, 34(44), 13368-13374 (2018-10-23)
Controlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying and emulating membrane functionality in synthetic biological systems. Here, we demonstrate an approach to reversibly control lipid
Zahra Aminipour et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 146, 133-142 (2019-11-08)
Doxorubicin is an anti-cancer drug that is important for breast cancer therapy. In this study, the effects of the membrane potential of breast cancer cells (-30 mV) and normal breast epithelial cells (-60 mV) on doxorubicin (DOX) permeability was studied. To achieve
M I Angelova et al.
Chemistry and physics of lipids, 101(1), 123-137 (2000-05-16)
DNA interactions with the bilayers of cationic liposomes were studied using a novel model experiment: DNAs were locally injected by a micropipette to a part of a giant unilamellar vesicle. The resulting phenomena were directly observed in optical microscope. Giant
H Lindsey et al.
Biochimica et biophysica acta, 555(1), 147-167 (1979-07-19)
We report here on a series of studies aimed at characterization of the structural and dynamical properties of the synthetic lipid diphytanoyl phosphatidylcholine, in multilamellar dispersions and vesicle suspensions. The lipid exhibits no detectable gel to liquid crystalline phase transition
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