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911240

Sigma-Aldrich

Poly(ethylene glycol) linear dendron

carboxyl terminated, PEG Mn 10,000, generation 4

Sinónimos:

Polyethylene glycol

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About This Item

Fórmula empírica (notación de Hill):
C594H1096O321
Peso molecular:
13374.87
UNSPSC Code:
51171641
NACRES:
NA.21

form

solid

mol wt

PEG Mn 10,000
generation 4

no. Surface Groups

16

color

white to off-white

storage temp.

−20°C

General description

  • Polymer architecture: PEG-linear dendron
  • Generation: 4
  • PEG average Mn: 10,000
  • End Group Functionality: Carboxylic acid
  • No. Surface Groups: 16
  • Calculated Mol. Wt.: 13374.98 g/mol
  • Bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolyzable linker allows for degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. This dendritic polymer is biocompatible, biodegradable, and suitable for biomedical applications. PEG-core dendrons feature excellent solubility in water and a high degree of functionality per PEG chain, enabling use for advanced drug delivery systems or for drug targeting. The carboxylic acid-functionalized corona can be readily used for bioconjugation reactions.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Artículos

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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