901577

t-Boc-N-amido-PEG_2-CH₂CO₂H

≥95%

• Fórmula empírica (notación de Hill): C₁₁H₂₁NO₆
• Número de CAS: 108466-89-3
• Peso molecular: 263.29
• MDL number: MFCD17019374
• UNSPSC Code: 51171641
• NACRES: NA.22

Propiedades

• assay: ≥95%
• form: liquid
• reaction suitability: reagent type: linker
• density: 1.15 g/cm³ (lit.)
• functional group: Boc; amine; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(COCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)
• Inchi Key: OMBVJVWVXRNDSL-UHFFFAOYSA-N

Descripción

Application

This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains two PEG units to help improve solubility.

t-Boc-N-amido-PEG₂-CH₂CO₂H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG₂-CH₂CO₂H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3